The Center for Drug Evaluation and Research is a division of the FDA that is responsible for making sure that drugs administered to people in the United States are both safe and effective. The CDER covers a wide variety of substances including generic, prescription, and over-the-counter drugs. The CDER keeps an eye on drugs that are not only in the pipeline but also those that are already on the market. The CDER also encourages the research of treatment of orphan diseases, or those that might not receive the same level of attention of more common conditions. The CDER also regulates substances such as toothpaste and shampoos.